I don’t know that particular amp but I have the same basic concept for any amp I play through - and that is to make sure you have plenty of low end, just a little bit of over drive (not the death metal setting) but enough to start breaking up the sound a bit. Then add about 30 / 40 % reverb. Keep your guitar volume at around 75% for most of what you play, and then all the way up for a solo (for a little extra punch). On that guitar of yours, I’d probably play through the neck pickups and get that nice bassy sound, and turn the guitar tone control (on the neck pickup) all the way to 10.
That’s my typical setting…. obviously some songs require more overdrive.. but i’d say that’s the biggest mistake people make in their tone is they try for too much distortion